Mixing and Stiring in Aerated Stirred Tank Bioreactor

Authors

PROF. MADYA Ts. Dr. NOOR AKHMAZILLAH BINTI MOHD FAUZI

Keywords:

Fermentation, harmaceuticals, stirring, bioprocess performance

Synopsis

Fermentation is a metabolic process carried out by microorganisms like yeast or bacteria and involves the conversion of sugars into other compounds such as acids, gases, or alcohol. This process is widely used in food production, and also utilized in industrial processes to produce various chemicals and pharmaceuticals. It is a fundamental aspect of biotechnology, food science, and microbiology, playing a crucial role in the production of many everyday products.

Mixing is crucial in fermentation to ensure even distribution of nutrients, oxygen supply for aerobic processes, efficient contact between microorganisms and substrate, heat dissipation, and prevention of stratification, ultimately leading to optimal product quality and yield. This book provides a deeper understanding on the various mechanisms employed for agitation in stirred tank fermenters, such as impellers, baffles, and spargers. Also, analyzing the power consumption associated with stirring and mixing operations, including factors such as impeller design, rotational speed, and viscosity of the fermentation broth.

The primary aim of this book is to be a comprehensive volume for stirring and mixing topic, ensuring that students not only grasp the fundamentals but also explore into the depths of understanding. With clear explanations and comprehensive notes, this book attempt to clarify the path toward mastery in this interesting topic.

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References

Asenjo J.A, Merchuk J.C (1996) Bioreactor System Design, Marcel Dekker, INC., New York.

Bailey, James E., and David F. Ollis. "Biochemical engineering fundamentals." McGraw-Hill, 1986.

Blanch, Harvey W., and Douglas S. Clark. "Biochemical engineering." CRC Press, 1997.

Bates R.L, Fondy P.L, and Corpstein R.R, (1963), An examination of some geometric parameters of impeller power. Ind. Eng. Chem. Process Des. Dev. 2, 310-314

Chisti, Y. (2006). Bioreactor design. Basic Biotechnology: Third Edition, m, 181–200. https://doi.org/10.1017/CBO9780511802409.009

Edward L. Paul, Victor A. Atiemo-Obeng, Suzanne M. Kresta, Edward L. Paul, Victor A. Atiemo-

Obeng, Suzanne M. Kresta, (2004) Handbook of Industrial Mixing. 1st edn. Wiley. Available at: https://www.perlego.com/book/2768849/handbook-of-industrial-mixing-science-and-practice-pdf (Accessed: 05 April 2024).

Ghosh, B., Bhattacharya, D., & Mukhopadhyay, M. (2018). Use of Fermentation Technology for Value-Added Industrial Research. Principles and Applications of Fermentation Technology, August, 141–161. https://doi.org/10.1002/9781119460381.ch8

Harvey P. S. Greaves M. (1982). Turbulent-Flow in an Agitated Vessel.2. Numerical-Solution and Model Predictions Transactions of the Institution of Chemical Engineers 60 (4), 201-210.

Holland F.A. and Chapman F.S. (1966), Liquid Mixing and Processing in Stirred Tanks, Reinhold, New York.

Jaibiba, P., Vignesh, S. N., & Hariharan, S. (2020). Working principle of typical bioreactors. In Bioreactors. INC. https://doi.org/10.1016/B978-0-12-821264-6.00010-3

Kaiser, S. C., Werner, S., Jossen, V., Blaschczok, K., & Eibl, D. (2018). Power input measurements in stirred bioreactors at laboratory scale. Journal of Visualized Experiments, 2018(135), 1–11. https://doi.org/10.3791/56078

Kuila A and Sharma V (2018). In Principles and Applications of Fermentation Technology. https://doi.org/10.1002/9781119460381

Mandenius, C.-F. (2016). Challenges for Bioreactor Design and Operation. Bioreactors, 1–34. https://doi.org/10.1002/9783527683369.ch1

Metzner A.B, Feehs, Lopez Ramos H., Otto R.E, and Tuthill J.D. (1961), Agitation of viscous Newtonian and non-Newtonian fluids. AIChE J. 7, 3-9.

Muniraj, I. K., Desikan, R., & Subburamu, K. (2019). Perspectives and Prospects of Fermentation

Technology. Advances in Food Bioproducts and Bioprocessing Technologies, July 2020, 217–232. https://doi.org/10.1201/9780429331817-10

Ng K. Fentiman N. J. Lee K. C. et al. (1998) Assessment of sliding mesh CFD predictions and LDA measurements of the flow in a tank stirred by a Rushton impeller Chemical Engineering Research & Design 76 A6 737- 747.

Pauline M. Doran, Bioprocess Engineering Principles, Second edition (2013). Elsivier. https://www.sciencedirect.com/book/9780122208515/bioprocess-engineering-principles.

Rose, A. H. (1985). Principles of fermentation technology. In Trends in Biotechnology (Vol. 3, Issue 9). https://doi.org/10.1016/0167-7799(85)90016-2

Rushton J.H, E.W. Costich E.W., and Everett H.J (1950), Power characteristics of mixing impellers. Parts I and II. Chem. Eng. Prog. 46, 395-404, 467-476.

Shuler M.L and Kargi F. (2002), Bioprocess Engineering Basic Concepts, Second Edition, Prentice Hall PTR.

Singh, J., Kaushik, N., & Biswas, S. (2014). Bioreactors – Technology & Design Analysis. April 2016, 27–36.

Spier, M. R., Vandenberghe, L. P. D. S., Medeiros, A. B. P., & Soccol, C. R. (2011). Application of different types of bioreactors in bioprocesses. In Bioreactors: Design, Properties, and Applications (Issue February 2016).

Uludag Y. Yapici K. Karasozen B. (2008). Numerical investigation of the effect of the Rushton type turbine design factors on agitated tank flow characteristics Chemical Engineering and Processing 47 (8), 1346-1355.

Viswalingam, K., & Solomon, F. E. (2013). A Comparative Study on Bio Reactors. Indian Journal of Economics and Development, May, 104–107.

Wang, S. J., & Zhong, J. J. (2007). Bioreactor Engineering. Bioprocessing for Value-Added

Products from Renewable Resources, 131–161. https://doi.org/10.1016/B978-044452114-9/50007-4

Yapici K. Karasozen B. Schafer M. (2008). Numerical investigation of the effect of the Rushton type turbine design factors on agitated tank flow characteristics Chemical Engineering and Processing 47, 1340 -1349

Yianneskis M. Popiolek Z. Whitelaw J. H. (1987) An experimental study of the steady and unsteady flow characteristics of stirred reactors Journal of Fluid mechanics 175, 537- 555

Zlokarnik M. and Judat H, (1988), Stirring. In: W. Gerhartz, Ed., Ullmann’s Encyclopedia of Industrial Chemistry, 5th ed., vol. B2, pp. 25-1, 25-33, VCH, Weinheim, Germany.

Zhong, J. J. (2010). Recent advances in bioreactor engineering. Korean Journal of Chemical Engineering, 27(4), 1035–1041. https://doi.org/10.1007/s11814-010-0277-5.

http://hejri.iauq.ac.ir/assets/subdomains/hejri/files/Books/mixing. Retrieved on March 22, 2024.

https://www.pctflow.com. Retrieved on March 20, 2024.

https://cdn.shopify.com – Baffles. Retrieved on January 15, 2024

https://cercell.com/bioreactor, Retrieved on January 10, 2024

http://www. hengko.com/bioreactor-sparger. Retrived on January 2, 2024

Mixing and Stiring in Aerated Stirred Tank Bioreactor

Published

23 September 2024

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Details about the available publication format: PDF

PDF

ISBN-13 (15)

978-629-490-098-1

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How to Cite

MOHD FAUZI , . N. A. (2024). Mixing and Stiring in Aerated Stirred Tank Bioreactor. Penerbit UTHM. https://publisher.uthm.edu.my/omp/index.php/penerbituthm/catalog/book/443