Preliminary Study on Delta-9-Tetrahydrocannabinol (∆9-THC): Hemispheric Lateralization with Behavioural Changes

  • Noor Azuin Suliman Universiti Putra Malaysia
  • Che Norma Mat Taib Universiti Putra Malaysia
  • Mohamad Aris Mohd Moklas Universiti Putra Malaysia
  • Zainul Amiruddin Zakaria Universiti Putra Malaysia
Keywords: Delta-9-Tetrahydrocannabinol (∆9-THC), hemispheric lateralization, assymmetric

Abstract

This study is designed inspired by the fact that there is an interhemisphere asymmetry of the brain region. A lot of researches studied in demonstrating the differences between right and left hemispheres of the brain. The objective of this preliminary study is to observe scientifically the effect of delta-9-tetrahydrocannabinol (∆9-THC) on the hemispheric lateralization with behavioural changes. Two regions of brain are selected, prefrontal cortex and hippocampus. Behavioural tests, namely heat stress test and novel-object discrimination test (NOD), were done on day seven. The hippocampus and prefrontal cortex regions of the brain were preceded to Western Blot technique in detecting c-fos. As for behavioural tests, heat stress and NOD and c-fos on hippocampus did not show significant differences. Meanwhile, the prefrontal cortex shows significant difference with p < 0.01. With these findings, reasonable dosages of ∆9-THC should be used to have statistically significant differences effects on behavioural tests. 

Author Biographies

Noor Azuin Suliman, Universiti Putra Malaysia
Department of Human Anatomy, Faculty of Medicine and Health Science, Universiti Putra Malaysia
Che Norma Mat Taib, Universiti Putra Malaysia
Department of Human Anatomy, Faculty of Medicine and Health Science, Universiti Putra Malaysia
Mohamad Aris Mohd Moklas, Universiti Putra Malaysia
Department of Human Anatomy, Faculty of Medicine and Health Science, Universiti Putra Malaysia
Zainul Amiruddin Zakaria, Universiti Putra Malaysia
Department of Pharmacology and Toxicology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
Published
2014-01-01
How to Cite
Suliman, N. A., Mat Taib, C. N., Mohd Moklas, M. A., & Zakaria, Z. A. (2014). Preliminary Study on Delta-9-Tetrahydrocannabinol (∆9-THC): Hemispheric Lateralization with Behavioural Changes. Journal of Science and Technology, 5(2). Retrieved from https://publisher.uthm.edu.my/ojs/index.php/JST/article/view/545
Section
Articles