Derivation of Repair and Mis-Repair DNA Double-Strand Breaks (DSBs) Model: A Case with Two Simultaneously DSBs Repair Condition

  • Muhamad Hanis Nasir Faculty of Ocean Engineering Technology and Informatics, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia
  • Fuaada Mohd Siam Faculty of Science, Universiti Teknologi Malaysia, 81310 Skudai, Johor Bahru, Malaysia
Keywords: structured ODEs, DNA repair, irradiation, DNA DSBs

Abstract

“A double-edged sword-like of ionizing radiation”, a common phrase used to describe the effect of irradiation to human cells. Our aim in this article is to study the dynamics of double-strand breaks (DSBs) damage on deoxyribonucleic acids (DNA) following irradiation. In particular, we derived a structured cell population model of DNA with respect to DSBs count and mis-repair DSBs, specifically in the present of two simultaneously DSBs repair. We also derived the characteristic of exact solution, which follows a Homologous-Cauchy condition of initial value problem. These results may give insights on modelling strategies of DNA response to irradiation.

Published
21-06-2020
How to Cite
Nasir, M. H., & Mohd Siam, F. (2020). Derivation of Repair and Mis-Repair DNA Double-Strand Breaks (DSBs) Model: A Case with Two Simultaneously DSBs Repair Condition. Journal of Science and Technology, 12(1), 1-6. Retrieved from https://publisher.uthm.edu.my/ojs/index.php/JST/article/view/5201
Section
Articles