Derivation of Repair and Mis-Repair DNA Double-Strand Breaks (DSBs) Model: A Case with Two Simultaneously DSBs Repair Condition

Authors

  • Muhamad Hanis Nasir Faculty of Ocean Engineering Technology and Informatics, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia
  • Fuaada Mohd Siam Faculty of Science, Universiti Teknologi Malaysia, 81310 Skudai, Johor Bahru, Malaysia

Keywords:

structured ODEs, DNA repair, irradiation, DNA DSBs

Abstract

“A double-edged sword-like of ionizing radiationâ€, a common phrase used to describe the effect of irradiation to human cells. Our aim in this article is to study the dynamics of double-strand breaks (DSBs) damage on deoxyribonucleic acids (DNA) following irradiation. In particular, we derived a structured cell population model of DNA with respect to DSBs count and mis-repair DSBs, specifically in the present of two simultaneously DSBs repair. We also derived the characteristic of exact solution, which follows a Homologous-Cauchy condition of initial value problem. These results may give insights on modelling strategies of DNA response to irradiation.

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Published

21-06-2020

Issue

Vol. 12 No. 1 (2020): Journal of Science and Technology

Section

Articles

License

Open access licenses

Open Access is by licensing the content with a Creative Commons (CC) license. 

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

 

How to Cite

Nasir, M. H., & Mohd Siam, F. . (2020). Derivation of Repair and Mis-Repair DNA Double-Strand Breaks (DSBs) Model: A Case with Two Simultaneously DSBs Repair Condition. Journal of Science and Technology, 12(1), 1-6. https://publisher.uthm.edu.my/ojs/index.php/JST/article/view/5201