Nano-Transfersomes of Vitamin-E and Aloe-Vera for The Management of Psoriasis

Nano- Transfersomes for the Management of Psoriasis

Abstract

Psoriasis is a dermal disease that causes red, itchy, scaly patches, most commonly on the knees, elbows, trunk and scalp. Psoriasis is an inflammatory condition, and aloe-vera, a natural product, reported to have anti-inflammatory properties. Further, vitamin-E has antioxidant properties and it can help to protect against some of the oxidative stress that occurs with psoriasis. Naturally, vitamin E has a wide range of benefits for health, skin, and hair. Present research aimed at formulation development and characterization of nano-transferosomes of vitamin-E and aloe-vera for the management of psoriasis. Nano-transfersomes pharmaceutical formulation was prepared characterized for particle size, Zeta potential, drug entrapment, shape and surface morphology, pH, viscosity, in vitro drug release, skin irritation, in vitro stability. The mean size, poly dispersity index (PDI), Zeta potential and entrapment efficiency of optimized nano-transfersomal vesicles formed were 156.5±0.98, 0.462, -23.9 Mv and 52.18±1.23% respectively. The prepared formulation showed prolonged drug release during the study of 12h. Vitamin-E and aloe-vera  containing nano-transfersome  was found to be highly efficacious in reducing the itching score in oxazolone-induced skin lesions in mice, divulged the therapeutic efficacy of natural formulation in sustainable, biodegradable and biocompatible manner in the management of psoriasis.