Nano-Transfersomes of Vitamin-E and Aloe-Vera for The Management of Psoriasis

Nano- Transfersomes for the Management of Psoriasis


  • Karishma Motwani Department of Pharmaceutical Sciences, Shalom Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences (SHUATS), Naini, Prayagraj, Uttar Pradesh, 211007, INDIA
  • Vandana Gupta Mittal Institute of Pharmacy, Opposite Bhopal Memorial Hospital & Research Centre, Ayodhya Bypass Road, Navi Bagh, Karond, Bhopal, Madhya Pradesh, 462038, INDIA


Nano-transfersomes, vitamin-E, aloe-vera, psoriasis, dermal disease, nano-formulation


Psoriasis is a dermal disease that causes red, itchy, scaly patches, most commonly on the knees, elbows, trunk and scalp. Psoriasis is an inflammatory condition, and aloe-vera, a natural product, reported to have anti-inflammatory properties. Further, vitamin-E has antioxidant properties and it can help to protect against some of the oxidative stress that occurs with psoriasis. Naturally, vitamin E has a wide range of benefits for health, skin, and hair. Present research aimed at formulation development and characterization of nano-transferosomes of vitamin-E and aloe-vera for the management of psoriasis. Nano-transfersomes pharmaceutical formulation was prepared characterized for particle size, Zeta potential, drug entrapment, shape and surface morphology, pH, viscosity, in vitro drug release, skin irritation, in vitro stability. The mean size, poly dispersity index (PDI), Zeta potential and entrapment efficiency of optimized nano-transfersomal vesicles formed were 156.5±0.98, 0.462, -23.9 Mv and 52.18±1.23% respectively. The prepared formulation showed prolonged drug release during the study of 12h. Vitamin-E and aloe-vera  containing nano-transfersome  was found to be highly efficacious in reducing the itching score in oxazolone-induced skin lesions in mice, divulged the therapeutic efficacy of natural formulation in sustainable, biodegradable and biocompatible manner in the management of psoriasis.




How to Cite

Motwani, K., & Gupta, V. (2022). Nano-Transfersomes of Vitamin-E and Aloe-Vera for The Management of Psoriasis: Nano- Transfersomes for the Management of Psoriasis. Journal of Sustainable Materials Processing and Management, 2(2), 9–18. Retrieved from