An Overview of Electrical Characterization Techniques for Biological Cell

  • Abdul Hafiz Mat Sulaiman Institute of Microengineering and Nanoelectronics, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.
  • Ida Laila Ahmad Instrumentation, Sensing and Tomography Research Group (InSet), Faculty of Electrical and Electronic Engineering, Universiti Tun Hussein Onn Malaysia, 86400 Batu Pahat, Johor, Malaysia.
  • Ruzairi Abdul Rahim Instrumentation, Sensing and Tomography Research Group (InSet), Faculty of Electrical and Electronic Engineering, Universiti Tun Hussein Onn Malaysia, 86400 Batu Pahat, Johor, Malaysia.
  • Jaysuman Pusppanathan Faculty of Biosciences & Medical Engineering, Universiti Teknologi Malaysia, 81310 Skudai Johor, Malaysia.
  • Dirman Hanafi Instrumentation, Sensing and Tomography Research Group (InSet), Faculty of Electrical and Electronic Engineering, Universiti Tun Hussein Onn Malaysia, 86400 Batu Pahat, Johor, Malaysia
  • Elmy Johana Mohamad Instrumentation, Sensing and Tomography Research Group (InSet), Faculty of Electrical and Electronic Engineering, Universiti Tun Hussein Onn Malaysia, 86400 Batu Pahat, Johor, Malaysia
  • Mohd Fadzli Abd Shaib Instrumentation, Sensing and Tomography Research Group (InSet), Faculty of Electrical and Electronic Engineering, Universiti Tun Hussein Onn Malaysia, 86400 Batu Pahat, Johor, Malaysia
  • Pei Ling Leow Process Tomography and Instrumentation Research Group (PROTOM-i), Faculty of Electrical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia.
  • Yasmin Abdul Wahab Department of Instrumentation & Control Engineering (ICE), Faculty of Electrical & Electronics Engineering, Universiti Malaysia Pahang, 26600, Pekan, Pahang, Malaysia.
  • Suzanna Ridzuan Aw Faculty of Electrical & Automation Engineering Technology, Terengganu Advance Technical Institute University College (TATiUC), Jalan Panchor, Telok Kalong, 24000 Kemaman, Terengganu, Malaysia.
Keywords: Electrical characterization, single cell, invasive, non invasive, biological cell

Abstract

In this paper, various electrical characterization techniques available for biological cell have been systematically reviewed. It covers both invasive and non-invasive approaches for population and single cell based studies. Examples of invasive technique consist of probing and patch clamp that measures the ionic current. However, depending on the applications, the non-invasive techniques are far more superior and popular. Some of the technique such as dielectric spectroscopy, electrorotation and dielectrophoresis measures the cell conductivity and dielectric constant. Furthermore, previous researchers proved that non-invasive technique may reduce the harmful effect on the cell due to electrical exposure. The review compares in terms of working principles, sample applications, advantages and limitations of each technique. 

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Author Biography

Ida Laila Ahmad, Instrumentation, Sensing and Tomography Research Group (InSet), Faculty of Electrical and Electronic Engineering, Universiti Tun Hussein Onn Malaysia, 86400 Batu Pahat, Johor, Malaysia.

Instrumentation, Sensing and Tomography Research Group (InSet), Faculty of Electrical and Electronic Engineering, Universiti Tun Hussein Onn Malaysia, 86400 Batu Pahat, Johor, Malaysia.

Published
12-09-2019
How to Cite
Mat Sulaiman, A. H., Ahmad, I. L., Abdul Rahim, R., Pusppanathan, J., Hanafi, D., Mohamad, E. J., Abd Shaib, M. F., Leow, P. L., Abdul Wahab, Y., & Ridzuan Aw, S. (2019). An Overview of Electrical Characterization Techniques for Biological Cell. International Journal of Integrated Engineering, 11(6), 166-175. Retrieved from https://publisher.uthm.edu.my/ojs/index.php/ijie/article/view/2726
Section
Articles